Fly into Benito Juarez International Airport (MEX), the closest airport, located 4.5 mi (7.3 km) from the city centre. If you're unable to find a flight that fits your schedule, you can also fly into Santa Lucía, Mexico (NLU-Felipe Ángeles Intl.), which is 22.3 mi (35.9 km) away.
You might consider catching a ride on the metro at Revolution Station for ease of access to the rest of the city.